Abstract:

Based on a response surface method， the influence of fused deposition modeling （FDM） technical parameters on the forming accuracy of preparing acetaminophen （APAP） tablets was explored， and the optimal experiment plan was obtained and verified. The results indicated that the factors affecting the horizontal and vertical dimensional errors of the APAP tablets prepared by FDM technology showed primary and secondary orders as follows： nozzle temperature > platform temperature > printing speed and nozzle temperature > printing speed > platform temperature， respectively. The interaction between the nozzle and platform temperatures had a significant effect on the forming accuracy of APAP tablets. The relative error of the optimized test plan was small and the result was reliable.

Key words: response surface methodology, fused deposition modeling, acetaminophen, forming accuracy