Abstract: The tribological behavior of blends of polyamide (PA66)/poly (vinylidene fluoride) （PVDF） reinforced with two different whiskers, potassium titanate (PTW) and calcium sulphate (CSW) was studied in this article. The effect of the different whisker content on the friction and wear property of the PA66/PVDF blends was investigated. The morphology of the microstructure, worn surface and transfer film of polymer material were analyzed using a scanning electron microscope. The chemical change of the blends before and after friction was analyzed by FTIR spectrometer. It was found that the self-lubricating and anti-wear property of the blends were lowered by the addition of PTW, the tribological property of the blends was enhanced by the addition of CSW. An obvious plastic deformation and adhesion were shown on the worn surface of the blend with PTW; lots of debris was adhered on the surface of counter steel ring. For the blend with CSW, lots of debris was adhered on the worn surface acting as lubricant under the shear action. Before and after friction, no chemical change occurred on the worn surface.