Abstract: The optimal processing parameters of A3B2C2D2E2F3G1 for the injection-compression molding of LED lens were obtained by simulating optimization using an orthogonal experiment matrix of L18(37), and the optical performance of the lens was evaluated. The results indicated that the reduction of interior residual stress and refractive index variation of lens is beneficial to the improvement of optical performance under the processing parameters of high compression speed and low injection rate. The refractive index variation of molded lens with hot runner was lower than that with cold runner. The light transmittance and maximum light intensity obtained with cold runner were 93.1 % and 590.3 cd, respectively, but both of them with hot runner were 4.4 % and 75 cd higher than those with cold runner. The injection-compression molding for LED lens with hot runner was superior to that with cold runner in the aspect of optical performance.