Abstract: Aiming at the breakage of automobile engine mount bracket, a multi-scale co-simulation technology was analyzed in comparison with the traditional simulation one, and their reliability was verified.A reasonable improvement plan was proposed on the basis of the overall stress distribution of the mount bracket. The overall stress level could be distributed within the safe range when the maximum stress was reduced by 32.57 %, and meanwhile the mass was reduced by 7.27 %. This lightweight design was successful for the automobile engine mount bracket.