分层可溶性利多卡因聚合物微针的制备与穿刺效果研究

doi:10.19491/j.issn.1001-9278.2019.12.002

中国塑料 ›› 2019, Vol. 33 ›› Issue (12): 7-10,57.DOI: 10.19491/j.issn.1001-9278.2019.12.002

分层可溶性利多卡因聚合物微针的制备与穿刺效果研究

张嘉荣,庄俭^*,吴大鸣,许红,郜王鑫,孙靖尧

北京化工大学机电工程学院

收稿日期:2019-07-30 修回日期:2019-08-28 出版日期:2019-12-26 发布日期:2020-01-17

Preparation and Puncturing Effect of Lidocaine-Containing Polymer Microneedles with Stratified Solubility

ZHANG Jiarong, ZHUANG Jian^*,WU Daming, XU Hong, GAO Wangxin, SUN Jingyao

College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology

Received:2019-07-30 Revised:2019-08-28 Online:2019-12-26 Published:2020-01-17

摘要/Abstract

摘要： 为研究高效利多卡因分层可溶性微针的制备工艺和皮肤穿刺效果，利用聚二甲基硅氧烷（PDMS）微针模具，选用聚乙烯醇（PVA）、透明质酸钠（HA）和聚乙烯吡咯烷酮（PVP）为复合材料，探究分步浇铸法和浇注黏合法制备微针阵列。同时，利用显微镜观察微针形态并且测量微针的形态，选用小鼠腹部皮肤进行穿刺试验并进行冷冻切片表征微针穿刺效果。结果表明，利多卡因分层可溶性微针成型率达100 %且成型周期缩短至4 h以内，药物主要集中在450 μm高的微针针体上，微针穿刺皮肤后恰好到达真皮层并且在皮肤上形成约250 μm深的微通道，微针针体能在5 min中内迅速溶解，为麻醉微针透皮给药实际应用提供一定技术依据。

Abstract: To understand the preparation process and skin-puncturing effect of microneedles with stratified solubility for efficient use of lidocaine, the polymer microneedles were prepared by two casting methods using polydimethylsiloxane as a negative model and the polyvinyl alcohol/sodium hyaluronate/polyvinylpyrrolidone compound as a composite matrix. The morphology of the resulting polymer microneedles was observed by a microscope, and their height was measured. The puncturing test was conducted on the abdominal skin of a mouse, and then the puncturing effect of microneedles was investigated upon the obtained frozen sections. The experimental results indicated that the lidocaine-containing polymer microneedles achieved a formation rate of 100 %, and lidocaine was mainly distributed in the needle bodies of the microneedles at a height of 450 μm. The microneedles were able to penetrate the skin just after reaching the dermis layer by giving a channel with a depth of about 250 μm through the skin. In addition, 90 wt% of the needle bodies dissolved rapidly within 5 min, and the molding cycle was shortened within 4 hours.

张嘉荣, 庄俭, 吴大鸣, 许红, 郜王鑫, 孙靖尧. 分层可溶性利多卡因聚合物微针的制备与穿刺效果研究[J]. 中国塑料, 2019, 33(12): 7-10,57.

ZHANG Jiarong, ZHUANG Jian, WU Daming, XU Hong, GAO Wangxin, SUN Jingyao. Preparation and Puncturing Effect of Lidocaine-Containing Polymer Microneedles with Stratified Solubility[J]. China Plastics, 2019, 33(12): 7-10,57.

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分层可溶性利多卡因聚合物微针的制备与穿刺效果研究

Preparation and Puncturing Effect of Lidocaine-Containing Polymer Microneedles with Stratified Solubility

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