Abstract: The relationship between microcapsule structure stiffness coefficient and Young's modulus of microcapsule shells was obtained in this paper by the combination of nanoindentation test and finite element analysis. According to the results of finite element analysis, the Young's modulus of microcapsule shell was 1.97 GPa and the failure stress was 52.42 MPa. The P-h curve obtained by finite element analysis was consistent with the experiment curve, which further proved the reliability of the simulate results.