Abstract: Aiming at the difficulty in the precise control for thermal-fluid-structure coupling deformation of permolded micro-component in the in-mold micro assembly molding process, an innovative precise shape control technology was proposed for the high-speed self-lubricating functional liquid membrane-assisted in-mold micro assembly molding.The results indicated that the high-speed self-lubricating functional liquid membrane-assisted in-mold micro assembly molding could make the thermal-fluid-structure coupling deformation of permolded micro-component controlled within a precision of several tens of micron, thus leading to a high precision for the in-mold micro assembly molding of polymeric micro mechanical system, Through a comparative analysis between the high-speed self-lubricating functional liquid membrane-assisted in-mold micro assembly molding and the traditional molding, the shape-control mechanism was exploited for the high-speed self-lubricating functional liquid membrane-assisted in-mold micro assembly molding.