Abstract: In this paper, a semi-interpenetrating (IPN)structural polydimethylsiloxane (PDMS)/polyvinylidene fluoride (PVDF)microporous membrane was prepared by a non-solvent induced phase separation method with tetraethyl orthosilicate (TEOS)as a crosslinking agent and then applied for the disposal of oil-in-water-type emulsified wastewater. The effect of operation conditions such as feed pressure, feed temperature and feed concentration on the separation performance of the membrane were studied. The experimental results indicated that the flux decreased with an increase of TEOS dosage, and however the oil removal efficiency was enhanced. Moreover, the flux was also improved with the increase of feed pressure, temperature and concentration, and the membrane achieved a maximum value of 31.93 L/m2·h in flux. The membrane exhibited an opposite trend in oil removal efficiency with the membrane flux, and its maximum efficiency reached 60.3 %.