Abstract: The waste rubber powder-modified Asphalt can not only improve the pavement performance of the asphalt pavement, but also can solve the environmental pollution problem caused by waste tires. In the paper, the effects of three different factors such as rubber powder content, rubber powder number, and hydrogen peroxide on the pavement performance of the mixture are systematically investigated through a rutting test and freeze-thaw splitting test. The experimental results indicated that the high-temperature stability and water stability of the rubber powders-modified asphalt mixture can be enhanced by increasing the content and fineness of rubber powders; however the performance of the road is only improved little or even reduced after incorporating the excessive amounts of rubber powders. An optimum content of 21 % and optimum fineness of 250 μm are recommended for the rubber powders used. Moreover, hydrogen peroxide is also able to improve the high-temperature stability and water stability of the rubber powders-modified asphalt mixture.