中国塑料 ›› 2023, Vol. 37 ›› Issue (12): 60-69.DOI: 10.19491/j.issn.1001-9278.2023.12.010

• 加工与应用 • 上一篇    下一篇

静电纺药物负载与应用研究进展

李好义1,2, 王逸铭2, 丁熙2, 张毅2, 白静雨3, 李斐菲4, 张跃勇4, 杨卫民1,2()   

  1. 1.北京化工大学生物医用材料北京实验室,北京 100029
    2.北京化工大学机电工程学院,北京 100029
    3.北京化工大学艺术与设计系,北京 100029
    4.北京茗泽中和药物研究有限公司,北京 102629
  • 收稿日期:2023-06-19 出版日期:2023-12-26 发布日期:2023-12-26
  • 通讯作者: 杨卫民(1965—),教授,主要研究方向:高分子材料先进制造,yangwm@buct.edu.cn
    E-mail:yangwm@buct.edu.cn

Research progress in electrospinning drug loading and its applications

LI Haoyi1,2, WANG Yiming2, DING Xi2, ZHANG Yi2, BAI Jingyu3, LI Feifei4, ZHANG Yueyong4, YANG Weimin1,2()   

  1. 1.Beijing Laboratory of Biomedical Materials,Beijing University of Chemical Technology,Beijing 100029,China
    2.School of Mechanical and Electrical Engineering,Beijing University of Chemical Technology,Beijing 100029,China
    3.Department of Art and Design,Beijing University of Chemical Technology,Beijing 100029,China
    4.Beijing Mingze Zhonghe Drug Research Co,Ltd,Beijing 102629,China
  • Received:2023-06-19 Online:2023-12-26 Published:2023-12-26
  • Contact: YANG Weimin E-mail:yangwm@buct.edu.cn

摘要:

利用静电纺微纳米纤维进行药物递送可以实现药物的可控释放,近年来逐渐成为研究热点。为进一步推动静电纺丝在药物释放领域的应用,首先从静电纺载药纤维的制备技术出发,介绍了溶液、乳液、熔体电纺在制备载药纤维方面的特点及优缺点;随后归纳了静电纺载药纤维在药物释放方面的影响因素和药物负载方式;最后总结了静电纺载药纤维在透皮给药、黏膜给药和组织工程领域的最新研究进展,挖掘静电纺丝在药物递送领域的应用潜力。

关键词: 静电纺丝, 药物释放, 多轴纤维, 微纳米纤维, 透皮给药, 组织工程

Abstract:

The use of electrospun micro/nanofibers for drug delivery can obtain a controllable drug release, which has gradually become a research hotspot in recent years. To further promote the application of electrospinning in the field of drug release, this paper introduced the characteristics, advantages, and disadvantages of solution, emulsion and melt electrospinning for the preparation of drug loaded fibers in view of the preparation technology of electrospun drug⁃loaded fibers. Subsequently, the influencing factors and drug loading forms of electrospun drug⁃loaded fibers in drug release were summarized. Finally, the latest research progress in the electrospun drug⁃loaded fibers in the fields of transdermal drug delivery, mucosal drug delivery and tissue engineering was reviewed, and the application potential of electrospinning in drug delivery was analyzed.

Key words: electrospinning, drug release, multiaxial fiber, micro and nanofiber, transdermal administration, tissue engineering

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