Abstract: In this paper, various methods for surface modification of poly(aryl ether ketone)s and their biomedical applications were described. The selective wet chemistry, plasma treatment, and the surface biofucntionalization via immobilization of extracellular matrix, e.g. fibronectin, were introduced. The application of such polymer as cell-culture substrates, trauma implants, load-bearing joint surface, and spine cages was also discussed. The future development in this area was forecast.

Key words: poly(aryl ether ketone), surface modification, cell culture, cell behavior, clinical application, implant