China Plastics ›› 2025, Vol. 39 ›› Issue (7): 6-11.DOI: 10.19491/j.issn.1001-9278.2025.07.002

• Materials and Properties • Previous Articles     Next Articles

Study on preparation and regulation of cationic polylactic acid nano⁃microparticles for vaccine adjuvant

ZHAO Xiaohuan(), WANG Yansen, SUN Jingshan, DENG Jingqian, QI Liya, HOU Dandan(), WANG Chunyao, TAN Xinyu   

  1. Sinopec (Beijing) Research Institute of Chemical Industry Co,Ltd,Beijing 100013,China
  • Received:2024-12-23 Online:2025-07-26 Published:2025-07-22

Abstract:

DDAB⁃PLA nano⁃microparticles were synthesized via an improved emulsification method, with particle size controlled by adjusting the oil/water phase ratio and emulsifier concentration. The cytotoxicity of DDAB⁃PLA particles with varying cationic contents was also evaluated. The resulting particles exhibited a nano⁃ to micro⁃scale size distribution, with an average diameter of approximately 490 nm. By modulating the aqueous phase volume and emulsifier concentration, the particle size could be precisely tuned within the range of 169~786 nm. Furthermore, DDAB⁃PLA nano⁃microparticles demonstrated negligible cytotoxicity toward L929 cells and DC, indicating excellent biocompatibility.

Key words: polylactic acid, emulsification method, nano?microparticle, particle size, vaccine adjuvant

CLC Number: