Abstract: In order to study the effect of processing parameters on the 250ml infusion bottle embryo’s injection molding properties, the mathematical model of which melt flowing in the mold cavity was set up on the basis of the heat transfer and plastics processing rheology theory. According to the principles of orthogonal experiment, the L16 (44) orthogonal test table of four factors and four levels by .the combined effect of. melt temperature, packing pressure, mold temperature, holding time and other parameters was established,. the infusion bottle embryo flowing molding process was simulated by using the Moldflow software, and the optimum process parameters were obtained using range and variance analysis method. By tryout test under the above conditions, the quality of the bottles embryo was qualified, size tolerance requirement was satisfied.