Study on pH⁃dependent Self⁃Assembly Behavior of Purely Hydrophilic Random Copolymers for Controlled Release of Active Substances

doi:10.19491/j.issn.1001-9278.2020.09.002

Abstract

Abstract:

It is very difficult to obtain a driving force from purely hydrophilic random copolymers self-assembly in water, and therefore the research on self-assembly is more complex due to random segment distribution and purely hydrophilicity. The molecular structure of poly(NVF-co-AA) was specially designed, and the controllable self-assembly could be obtained via a variation of pH responsiveness. The results indicated that the spherical self-assembly aggregates could be formed at pH 9.0~7.4. When pH value decreased to 5.0, these spherical self-assembly aggregates disintegrated into some small aggregates. The morphology of self-assembly aggregates was still stable with the temperature rising up to 38 ℃. The embedding and controlled release of alpha-arbutin were realized by using this controllable self-assembly structure. The results indicated that more than 90 % of alpha-arbutin could be entrapped stably at pH 9.0~7.4 and 20~38 ℃, and the cumulative release rate of alpha-arbutin was over 95 % within 100 min under a skin environment of pH 5.0 and 38 ℃.

Key words: purely hydrophilic random copolymers, aqueous self-assembly, alpha-arbutin, pH-dependent, controlled release of active substances

CLC Number:

TQ325.1

YANG Lu, CHEN Hanting. Study on pH⁃dependent Self⁃Assembly Behavior of Purely Hydrophilic Random Copolymers for Controlled Release of Active Substances[J]. China Plastics, 2020, 34(9): 9-15.

Figures/Tables 6

n_NVF:n_AA	AA质量分数/%	M_n/×10⁴	M_w/×10⁴	M_w/M_n
30∶70	65.5	0.99	1.14	1.15
50∶50	51.8	0.62	0.77	1.24
70∶30	32.1	0.98	1.75	1.84

Tab.1. Mole ratios of monomers and GPC results of the poly(NVF?co?AA) family

Fig.1. The effect of different initiator dosage on the polymerization of poly(NVF?co?AA)

Fig.2. Effect of different reaction temperature on the polymerization of poly(NVF?co?AA)

Fig.3. ATR?FTIR spectra of poly(NVF?co?AA)

Fig.4. TEM images of poly(NVF?co?AA) self?assemblies at different pH

Fig.5. Alpha?arbutin release curves of poly(NVF?co?AA) self?assemblies

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