Research progress in effect of pore structure on performance of 3D printed bone tissue scaffolds

doi:10.19491/j.issn.1001-9278.2022.12.021

Abstract

Abstract:

This paper reviewed the research status of the microstructure of scaffold pores from five aspects， including the pore shape， pore size， porosity， surface roughness， and connection pathways of bone tissue engineering scaffolds. The pore shape of the scaffold with a gradient structure was found to be closer to those of the natural bone. The rough surface can improve the cell adhesion and proliferation of the scaffolds， and the internal structure of the non⁃orthogonal connection pathway can provide a dynamic growth space for later bone regeneration.

Key words: three dimensional printing, bone tissue, scaffold, structure, property

CLC Number:

TQ 320.6

ZHANG Weimeng, WANG Jie, HU Jing. Research progress in effect of pore structure on performance of 3D printed bone tissue scaffolds[J]. China Plastics, 2022, 36(12): 155-166.

Figures/Tables 12

Fig.1. Simple scaffold structure［38］

Fig.2. Structure and performance of the scaffolds［44］

Fig.3. Pore size gradient change structure ［60］

Fig.4. The simulated scaffold， combined with haversian tube， Volkmann tube and cancellous bone structure， based on a multicellular delivery system， helping to form new bones and new blood vessels［66］

Fig.5. Scaffold structures with different shapes， pore sizes and porosity［67］

Fig.6. Hollow support structure scaffold［73］

Fig.7. SEM for six groups of scaffold surfaces［87］

Fig.8. Predicting the area of bone formation in the scaffold hole［99］

Fig.9. The internal microporous channel structure（a） and the scaffold structure model （b）［68］

Fig.10. Refinement of different micro⁃pore channel structures［68］

Fig.11. Model diagram and finite element analysis cloud diagram of face centered cubic structure of spherical hole and conventional orthogonal cylindrical structure［39］

Fig.12. SEM micrographs ［92］

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