Research progress in electrospinning drug loading and its applications

doi:10.19491/j.issn.1001-9278.2023.12.010

Abstract

Abstract:

The use of electrospun micro/nanofibers for drug delivery can obtain a controllable drug release， which has gradually become a research hotspot in recent years. To further promote the application of electrospinning in the field of drug release， this paper introduced the characteristics， advantages， and disadvantages of solution， emulsion and melt electrospinning for the preparation of drug loaded fibers in view of the preparation technology of electrospun drug⁃loaded fibers. Subsequently， the influencing factors and drug loading forms of electrospun drug⁃loaded fibers in drug release were summarized. Finally， the latest research progress in the electrospun drug⁃loaded fibers in the fields of transdermal drug delivery， mucosal drug delivery and tissue engineering was reviewed， and the application potential of electrospinning in drug delivery was analyzed.

Key words: electrospinning, drug release, multiaxial fiber, micro and nanofiber, transdermal administration, tissue engineering

CLC Number:

TQ325

LI Haoyi, WANG Yiming, DING Xi, ZHANG Yi, BAI Jingyu, LI Feifei, ZHANG Yueyong, YANG Weimin. Research progress in electrospinning drug loading and its applications[J]. China Plastics, 2023, 37(12): 60-69.

Figures/Tables 5

References 69

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种类	优点	缺点	参考文献
溶液电纺载药	工艺简单、适用材料广泛	污染、生产效率低、纤维力学性能差	［13⁃18］
乳液电纺载药	装置简单、纤维有缓释壳⁃核结构	乳液配制要求高	［20⁃24］
熔体电纺载药	避免污染、连续性好、纤维结晶度高、纤维力学性能好	加工温度高限制热稳定性差的药物使用、装置较复杂	［8，25⁃28］

种类	优点	缺点	参考文献
溶液电纺载药	工艺简单、适用材料广泛	污染、生产效率低、纤维力学性能差	［13⁃18］
乳液电纺载药	装置简单、纤维有缓释壳⁃核结构	乳液配制要求高	［20⁃24］
熔体电纺载药	避免污染、连续性好、纤维结晶度高、纤维力学性能好	加工温度高限制热稳定性差的药物使用、装置较复杂	［8，25⁃28］

来源	变量	程度	释放路径	影响	释放能力	参考文献
纤维	直径	↑	↑	延长路径	↓	［5⁃6，34⁃35，38］
	孔隙	↑	↓	提供捷径	↑	［31⁃33］
	结构	多轴	-	屏障变多	↓	［4，7，42⁃44］
	结晶度	↑	-	有序结构屏障变多	↓	［25］
药物	浓度	↑	↓	屏障变少	↑	［25，39⁃40］
药物	结晶度	↑	⁃	纤维包覆程度下降	↑	［7，36，41］

来源	变量	程度	释放路径	影响	释放能力	参考文献
纤维	直径	↑	↑	延长路径	↓	［5⁃6，34⁃35，38］
	孔隙	↑	↓	提供捷径	↑	［31⁃33］
	结构	多轴	-	屏障变多	↓	［4，7，42⁃44］
	结晶度	↑	-	有序结构屏障变多	↓	［25］
药物	浓度	↑	↓	屏障变少	↑	［25，39⁃40］
药物	结晶度	↑	⁃	纤维包覆程度下降	↑	［7，36，41］

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