Gimini Quaternary Ammonium Salt⁃modified PVC⁃based Antibacterial Materials for Medical Use

doi:10.19491/j.issn.1001-9278.2021.07.009

Abstract

Abstract:

To solve the problem that poly（vinyl chloride）（PVC） medical consumables are easily infected by bacteria during the use， a new type of antibacterial agent， C_8?6?8 gimini quaternary ammonium salt （GQAS）， was synthesized. This new quaternary ammonium salt was then used as an additive to blend with PVC physically. The resultant blends were compressed to pellets as a type of modified PVC materials with good antibacterial properties. The structure and thermal stability of GQAS and the antibacterial properties， dissolution capacity and mechanical properties of modified PVC materials were characterized using nuclear magnetic resonance spectrometer， thermogravimetric analyzer， colony counter， and electronic universal material testing machine. The results indicated that GQAS did not decompose with heating when blended with PVC. The modified PVC material containing 5 wt% GQAS can effectively inhibit the growth of E.coli and S.aureus. After soaked for 7 days， the modified PVC materials containing 5 wt% GQAS still had a good antibacterial capability. The modified PVC materials showed a decrease in tensile strength（22.3 or 18.9 MPa） and elongation at break（318.8 % or 295.3 %） comparing with pure PVC（24.6 MPa，341.5 %）， which was still in an acceptable range.

Key words: gimini quaternary ammonium salt, poly（vinyl chloride）, antibacterial, blending, migration

CLC Number:

TQ325.3

ZHANG Yaocheng, WU Yongzhen, LI Yang, ZHAO Zhu, WANG Guosheng, DING Xuejia. Gimini Quaternary Ammonium Salt⁃modified PVC⁃based Antibacterial Materials for Medical Use[J]. China Plastics, 2021, 35(7): 53-57.

Figures/Tables 6

Fig.1. 1H?NMR spectrum of C8?6?8 gimini quaternary ammonium salt

Fig.2. TG curve of GQAS

Fig.3. Antibacterial photos of modified PVC

Fig.4. Inhibition zones of antibacterial PVC after being soaked for 0， 1， 3， 5 and 7 days

GQAS

含量/%

Tab.1. Statistics of the diameter of the inhibition zones

项目	GQAS含量/%
项目	0	2	5
拉伸强度/MPa	24.6±1.5	22.3±2.6	18.9±2.8
断裂伸长率/%	341.5±15.9	318.8±32.0	295.3±35.2

Tab.2. Tensile strength and elongation at break of modified PVC with different content of GQAS

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