Abstract: A new unsaturated poly（ester-amide）resin was synthesized and characterized, and nano-hydroxyapatite（n-HA）was used to strengthen unsaturated poly（ester-amide）.UPEA possessed an excellent thermal stability. Upon being loaded with n-HA, the flexural property of UPEA increased. When the n-HA content exceeded 10 %, flexural properties decreased. However, a high content of n-HA may reduce the decay rate and mass loss rate during the first 3 months of the degradation. After a hydrolysis in a 1.0 mol/L NaOH standard solution for 10 days, the more the n-HA content, the higher the rate of hydrolysis.

Key words: unsaturated poly（ester-amide）resin, nano-hydroxyapatite, composite, bending property, degradation property