关键词: 姜黄素, 聚己内酯, 支架, 缓释, 释药模型

Abstract:

Polycaprolactone （PCL）/curcumin （CUR） porous scaffold materials were prepared using a solution⁃casting method， and their porosity and drug loading and sustained release behaviors were investigated using scanning electron microscopy and thermogravimetric analysis. The in vitro drug release model of the scaffold materials was also analyzed. The results indicated that the drug release model of the scaffold materials conformed to the first⁃order equation at a CUR content of 2 wt%， a PCL concentration of 10 wt% in acetic acid， and a chitosan content of 2.86 wt% in the scaffold materials. The scaffold materials presented porosity of over 95 %， resulting in a drug loading of 1.63 %. In the phosphate buffer solution， the cumulative release rate of CUR for 90 h was 76.2 %. For other formulations， the scaffold materials showed porosity of above 95 %， and their cumulative slow⁃release rate of CUR for 90 h was between 60 % and 87 %. This demonstrated that the developed scaffold materials had ideal porosity and obvious sustained⁃release effect of CUR drug， exhibiting a good application prospect in the tissue⁃engineering field.

Key words: curcumin, polycaprolactone, scaffold, sustained release, drug release model