Synthesis of 3-Arylbenzofunanone Analogues

doi:10.19491/j.issn.1001-9278.2015.10.005

Abstract

Abstract: Starting from 50ω% aqueous glyoxylic acid and 2,4-di-tert-butylphenol，synthesized 3-(3,4-dimethylphenyl)-5,7-di-tert-butyl-methyl-3H-benzofuran-2-one by" process esterification addition - alkylation- extractive crystallization", and studied the effects of process parameters on the yield of the target product comprehensively and systematically. The synthesis reaction conditions were optimized, the yield of target product reaches 70.2% when the molar ratio of glyoxylic acid and alkylphenol equales to 1.3:1, at 100℃, reaction 3h, in esterification addition reaction, and when the molar ratio of catalyst to alkylphenol is 0.12:1, at -0.06MPa, reaction 2.5h, in alkylation.

Key words: 3-Arylbenzofunanone, antioxidan, antitumor activity, synthesis

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Synthesis of 3-Arylbenzofunanone Analogues

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