Effect of poly（lactic acid）⁃co⁃hydroxyacetic acid copolymer coating on performance of poly（lactic acid） 3D printed scaffolds

doi:10.19491/j.issn.1001-9278.2023.01.001

Abstract

Abstract:

Three⁃dimensional porous poly（lactic acid）（PLA） scaffolds with a porosity of 61.7 % and good connectivity were prepared by using a 3D⁃printing technology. Then， PLA/poly（lactic acid⁃co⁃hydroxyacetic acid） copolymer （PLGA） composite scaffolds were prepared by coating PLGA on the surface of the PLA scaffolds with different concentrations of PLGA using a dip⁃coating method. The effects of PLGA concentrations on the properties of PLA scaffolds such as cross⁃sectional microscopic morphology， scaffold surface hydrophilicity， mechanical strength， and the cell proliferation activity on the scaffolds were investigated by using scanning electron microscopy， contact angle analyzer， universal testing machine， and cell counting Kit⁃8. The results indicated that the PLGA⁃coated PLA scaffolds presented a significant decrease in contact angle compared to the PLA scaffolds without a PLGA coating. They exhibited the smallest contact angle of 64.7 ° ± 1.1 ° at a PLGA mass fraction of 6 %. The cell activity on the surface of PLGA/PLA composite scaffolds was enhanced significantly after the cell inoculation for 24 h.

Key words: 3Dimension printing, scaffold, poly（lactic acid）, poly（lactic acid?co?hydroxyacetic acid） copolymer, coating

CLC Number:

TQ321

WANG Jie, ZHANG Weimeng, HU Jing. Effect of poly（lactic acid）⁃co⁃hydroxyacetic acid copolymer coating on performance of poly（lactic acid） 3D printed scaffolds[J]. China Plastics, 2023, 37(1): 1-7.

Figures/Tables 5

Fig.1. Surface section morphology of PLA scaffold coated with PLGA solution

Fig.2. SEM of PLGA solution⁃coated PLA scaffold after compression

Fig.3. Compression strength of the PLA scaffold coated with different concentrations of PLGA solution

Fig.4. Water contact angles of the PLA scaffold coated with different concentrations of PLGA solution

Fig.5. Cell activity and adhesion on the scaffold surface

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